I recently learned that I have a SNP, Rs10994336, that is highly expressed in people diagnosed with Bipolar disorder. This is responsible expression of a protein, that modulates how the signals in the prefrontal cortex propagate. The uncommon mutation causes signals to attentuate, due to a sodium channel imbalance. A study has shown that mutation carriers are more prone to anhedonia.
Lamotrigine inhibits Glumate, which is the main excitatory neurotransmitter. Too much, is believed to cause signals to fail to propagate through parts of the frontal brain.
Additional research has shown that long-term Lamotrigine usage, increases activity in parts of the pre-frontal cortex, long believed to be underactive when compared to the stiatum in Bipolar patients.
I haven't been officially diagnosed with Bipolar disorder, but am beginning to believe, based on my history that I may have some minor form. Their have been a few episodes in my adolescence, that resulted either in arrests or trips to the hospital. I was raised in a good-upbringing, but contrary to that, hung out with the wrong people. I've been able to shake that past for the most part and graduate college and get a good job.
This seems great: I now spend most my days, productive and content working in the moment. But I feel often that I'm living to avoid my fears, rather than pursue my higher goals. I'd attribute this to a form of anticipatory anhedonia.
I'm curious if any Lamotrigine users can attest to it's affects, and if I'm setting false expectations.
edit-spelling
I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.
Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.
Do your worst!
I'm surprised it hasn't decade.
For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.
I said "hey look, an escaPEA"
No one near me but it didn't half make me laugh for a good hour or so!
Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂
It really does, I swear!
Because she wanted to see the task manager.
Heard they've been doing some shady business.
They’re on standbi
Pilot on me!!
Nothing, he was gladiator.
Dad jokes are supposed to be jokes you can tell a kid and they will understand it and find it funny.
This sub is mostly just NSFW puns now.
If it needs a NSFW tag it's not a dad joke. There should just be a NSFW puns subreddit for that.
Edit* I'm not replying any longer and turning off notifications but to all those that say "no one cares", there sure are a lot of you arguing about it. Maybe I'm wrong but you people don't need to be rude about it. If you really don't care, don't comment.
What did 0 say to 8 ?
" Nice Belt "
So What did 3 say to 8 ?
" Hey, you two stop making out "
When I got home, they were still there.
I won't be doing that today!
[Removed]
Where ever you left it 🤷♀️🤭
This morning, my 4 year old daughter.
Daughter: I'm hungry
Me: nerves building, smile widening
Me: Hi hungry, I'm dad.
She had no idea what was going on but I finally did it.
Thank you all for listening.
There hasn't been a post all year!
You take away their little brooms
It was about a weak back.
Or would that be too forward thinking?
It’s pronounced “Noel.”
After all his first name is No-vac
What, then, is Chinese rap?
Edit:
Notable mentions from the comments:
-
Spanish/Swedish/Swiss/Serbian hits
-
French/Finnish art
-
Country/Canadian rap
-
Chinese/Country/Canadian rock
-
Turkish/Tunisian/Taiwanese rap
There hasn't been a single post this year!
(Happy 2022 from New Zealand)
Nothing, it just waved
Him: I can explain everything!
(It's his best joke yet I think)
