European Commission Grants Ocugen Orphan Medicinal Product Designation for Gene Therapy Product Candidate, OCU400, For the Treatment of Both Retinitis Pigmentosa and Leber Congenital Amaurosis February 23, 2021 at 7:30 AM EST
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European Commission Grants Ocugen Orphan Medicinal Product Designation for Gene Therapy Product Candidate, OCU400, For the Treatment of Both Retinitis Pigmentosa and Leber Congenital Amaurosis February 23, 2021 7:30 AM EST
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πŸ‘€︎ u/digitalcredits
πŸ“…︎ Feb 23 2021
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European Commission Grants Ocugen Orphan Medicinal Product Designation for Gene Therapy Product Candidate, OCU400, For the Treatment of Both Retinitis Pigmentosa and Leber Congenital Amaurosis February 23, 2021 at 7:30 AM EST
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πŸ“…︎ Feb 23 2021
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Creationist 'Orphan Gene' arguments explicitly exclude Baraminology: according to DI, the Flood never could have happened

So, recently, a creationist just kept repeating "orphans genes" at me: an orphan gene is a gene that exists only within a narrow subfamily, which strongly implied when it arose. Humans have some ~1000 - 2000 orphan genes compared to our closest ape relatives, which is not abnormal: most species have approximately 10 - 30% of their genes being "taxonomically restricted".

The methods they arise from are not unknown: de novo arise; gene duplication and rapid mutation; and horizontal gene transfer. None of these can be ruled out, though some are more common than others. What I note from creationists is that none of them can explain why orphan genes are a problem, but simply point to the pile and say "evolution bad", as if the number of genes and the timeline given are going to trip us up.

...but then I realized something: if the Flood happened 4000 years ago, where did these genes come from? It has been less than 1000 generations since the Flood, for most organisms, so there is absolutely no fucking way these genes should have evolved in that time, if it was going to be a problem on the 6-12 million year timeline that human evolution required. Unlike human or animal evolution, they have a much smaller population and a much shorter timeline: so there is no way that the taxonomically restricted genes could exist if all the horse species, for example, are descended from the handful of horses on the ark.

So, creationists: if the orphan gene argument is so good, how does it not exclude the Flood from occurring?

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πŸ‘€︎ u/Dzugavili
πŸ“…︎ Apr 18 2021
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[Orphan Black] What is the in-world threat that DYAD's possessions of clone gene patents poses to the clones' day to day lives? Is it believable to think DYAD can "own" the clones? Or control their lives? Or control their reproductive choices?

I like this show, but I think the ownership of gene patents makes zero difference to the clones' day to day lives.

No court, no court of public opinion is going to let DYAD own the clones.

What am I missing?

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πŸ‘€︎ u/jpflathead
πŸ“…︎ May 24 2014
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Orphans of the Left: "Proponents of various social justice movements routinely express support for each other – feminist organisations often show support for Black Lives Matter, or for immigrant rights, or gay rights – but animal rights groups remain outside this circle of progressive solidarity."

These aren't new ideas or publications, but I figured they're more relevant than ever, given the recent discourse around AR/veganism

Full journal article: Kymlicka, W. and Donaldson, S. (2014), Animal Rights, Multiculturalism, and the Left. J Soc Philos, 45: 116-135. doi:10.1111/josp.12047

Kymlicka's magazine article on the same topic: Human Supremacism: Why are animal rights activists still "orphans of the left"?

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πŸ‘€︎ u/observerkid
πŸ“…︎ May 18 2020
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[Fanatical] Black Friday Sale Day 7 (Flash Deals – Pumpkin Jack (-65%), Hell Let Loose (-37%), Judgment: Apocalypse Survival Simulation (-55%))

Hi Reddit, Black Friday may have been and gone but it doesn’t mean that our Flash Deals stopped launching. Check out the final three deals on the Black Friday Sale before the timer hits 0.

Plus, when you spend over $10/Β£8/€10 in a single order you will get a free mystery game on us.

TODAY’S FLASH DEALS

Title DRM Fanatical Discount USD GBP EUR
Hell Let Loose Steam 37% $25.19 Β£22.04 €25.19
Judgment: Apocalypse Survival Simulation Steam 55% $8.99 Β£6.97 €8.99
Pumpkin Jack Steam 65% $10.49 Β£8.74 €10.49

TOP SELLERS OF THE SALE

Title DRM Fanatical Discount USD GBP EUR
Horizon Zero Dawnβ„’ Complete Edition Steam 56% $21.99 Β£17.59 €21.99
Control Ultimate Edition Steam 76% $9.59 Β£8.39 €9.59
Days Gone Steam 50% $24.99 Β£19.99 €24.99
DEATH STRANDING Steam 76% $14.39 Β£13.19 €14.39
Shin Megami Tensei III Nocturne HD Remaster Steam 51% $24.49 Β£22.04 €24.49
DEATHLOOP Steam 57% $25.79 Β£21.49 €25.79
Resident Evil Village - Deluxe Edition Steam 49% $36.47 Β£29.97 €36.47
Red Dead Redemption 2: Ultimate Edition Rockstar 63% $37.49 Β£29.99 €33.74
Monster Hunter World: Iceborne Master Edition Steam 50% $29.99 Β£24.99 €29.
... keep reading on reddit ➑

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πŸ‘€︎ u/WeAreFanatical
πŸ“…︎ Nov 28 2021
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Mother Henriette DΓ­az DeLille (1813 – 1862) was a Black Catholic nun in the United States who founded the Sisters of the Holy Family in 1836. Composed of free women of color, the order provided nursing care and a home for orphans. sdcason.com/who-was-vener…
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πŸ‘€︎ u/shalone86
πŸ“…︎ Dec 01 2020
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[Rewatch] 1990s OVAs – Black Jack (episode 7)

#Rewatch: 1990s OVAs – Black Jack (episode 7)

MAL | ANN1 ANN2 | AniDB1 AniDB2 | Anilist1 Anilist2

<- Previous Episode | Index | Next Episode ->

Staff corner

Catherine is voiced by Han, Keiko. She had an early role as Lalah Sune in MSG, but started working even earlier in 1974 in Barbapapa. Some of her other roles are: Saori Kido from Saint Seiya, Luna from Sailor Moon, as well as Andromeda, from The Queen of a Thousand Years.

Yasuhiko is also voiced by an old hand, Yuu, Mizushima. He stared in several TV series during the late 1970 and 1980s, the most well-known of which is probably Voltron, where he voices Isamu Kurogane. He is also Ryou Asuka from Devilman, Neidhardt MΓΌller from LotGH, and Reed Clow from Tsubasa Chronicle.

Questions

  1. Did mixing multiple plots in this episode work?
  2. Where do you stand on Yasuhiro’s argument about medical justice? About following proper rules?
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πŸ‘€︎ u/No_Rex
πŸ“…︎ Dec 07 2021
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Mother Henriette DΓ­az DeLille (1813 – 1862) was a Black Catholic nun in the United States who founded the Sisters of the Holy Family in 1836. Composed of free women of color, the order provided nursing care and a home for orphans. sdcason.com/who-was-vener…
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πŸ‘€︎ u/shalone86
πŸ“…︎ Dec 01 2020
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European Commission Grants Ocugen Orphan Medicinal Product Designation for Gene Therapy Product Candidate, OCU400 twitter.com/ocugen/status…
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πŸ‘€︎ u/EGO822
πŸ“…︎ Feb 23 2021
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On friday 7 January here 22 people died due to cold in a city. As I have posted many times about homeless orphans kids that I teach. Weather is too cool and heavy rain is making it more difficult for homeless orphans to bear it. Kids are getting sick due to cold weather. Love and prayers are needed reddit.com/gallery/rzxurs
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πŸ‘€︎ u/Saminarex
πŸ“…︎ Jan 09 2022
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Orphan genes

I’ve just come here to ask a question I don’t have the answer to. I believe in evolution, of course, but I’m truly confused about Orphan genes. May anyone be able to provide an explanation/answer?

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πŸ‘€︎ u/CrimsonBreath
πŸ“…︎ Jan 29 2021
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Razer Kraken Tournament Edition THX 7.1 Surround Sound Gaming Headset: Retractable Noise Cancelling Mic - USB DAC - For PC, PS4, PS5, Nintendo Switch, Xbox One, Xbox Series X & S, Mobile – Black. Now: $86.62 After $13.37 (13% Off) progamerstech.com/product…
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πŸ‘€︎ u/fifa2003
πŸ“…︎ Jan 07 2022
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[SPOILERS]Any other Orphan Black fans...

...getting more and more of a Helena vibe from Yelena? Especially during her scene at Kate's house with the mac and cheese, I kept expecting her to say "sestra". I'm starting to wonder if it's a bit of an intentional nod to Tatiana Maslany from Florence Pugh (who's really hilarious btw, just as she was in BW).

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πŸ‘€︎ u/GeneSequence
πŸ“…︎ Dec 18 2021
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On friday 7 January here 22 people died due to cold in a city. As I have posted many times about homeless orphans kids that I teach. Weather is too cool and heavy rain is making it more difficult for homeless orphans to bear it. Kids are getting sick due to cold weather. Love and prayers are needed reddit.com/gallery/rzxybr
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πŸ‘€︎ u/Saminarex
πŸ“…︎ Jan 09 2022
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Orphan Black was such a unique show. I can't help but feel nostalgic for it now and wish they kept it going... or at the very least bring the team back for a new show.

5 seasons was a pretty good length, but a spin-off show would have been nice. Or even now that time has passed, I feel like they could just bring it back. There's been nothing like it since. It was such an amazing platform and showcase of one actors talents, but even beyond that the show had such a great blend of genres that kept it interesting. It was funny, it was dark, it was emotional, it was just a lot of fun.

I don't know if I should give John Fawcett all the credit, but he made my favorite movie as a teen - Ginger Snaps. So, the fact he also years later made my favorite television show is quite the coincidence. So, if not Orphan Black, then maybe a new show. Obviously, hopefully starring Tatiana.

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πŸ‘€︎ u/Ghastion
πŸ“…︎ Dec 05 2021
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Hi can someone recommend me shows like Alice in borderland, orphan black, bates motel? I know the genres arent the same but :)
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πŸ“…︎ Jan 05 2022
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Wow!!! It Wasn’t Just Beagles and Monkeys – Fauci’s NIH Also Funded Medical Experiments on AIDS Orphans in NY City. Link in comments
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πŸ“…︎ Oct 26 2021
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Tatiana Maslany [Orphan Black]
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πŸ‘€︎ u/NotRealOpinions
πŸ“…︎ Jan 05 2022
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The Bishop Maze Puzzle! In this maze, white has to move the bishop consecutively until it captures the black king. It cannot move to squares that are attacked by black pieces. The bishop can capture the king in 7 moves – can you find your way through the maze?
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πŸ‘€︎ u/Only_Birdies
πŸ“…︎ Aug 01 2021
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$CTXR β€œONTAK” is approved in Japan and was FDA approved with a different formulation in USA $CTXR has the BLA exclusivity (limits competition 12 years), orphan drug designation ( 7 years exclusivity), patents pending and manufacturing process is a trade secret of ONTAK. Great dip recently to buy
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πŸ‘€︎ u/lyon-
πŸ“…︎ Nov 11 2021
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