Its been working but Ive read so much conflicting infomraiton here.

Its a now foods brand. https://www.amazon.com/Foods-Magnesium-Transporters-Capsules-Count/dp/B07JQFPL61

All of my information has been compiled from examine.com, and in cases where I did not find the research sufficient (namely Rosmarinic Acid), I found a scientific study to cite. My goal was to compile a bunch of GABAergics into digestible bullet-points for future reference in creating stacks.

I also included a few non-GABAergics that I wanted to know more about.

IF ANY INFORMATION IS WRONG, please let me know, ideally with a source attached so I can amend the document :)

ALSO, the synergies / stacks at the bottom are just speculation, I have not tried these yet nor can I confirm if they are effective.

Helpful information

• GABA receptor sites
  • A
    • alpha-1: addictive, tolerance building, impairing, sedating, amnesia (i.e. benzos)
    • alpha-2 and alpha-3: reduced abuse potential, anxiolytic and muscle relaxation
    • alpha-5: memory impairment
  • B: effects are similar to GABAA but less sedating, typically more clear headed (i.e. baclofen, GHB, phenibut)
• Enzymes
  • GABA-transaminase (GABA-T): GABA → glutamate
  • Glutamate decarboxylase (GAD): glutamate → GABA
• Glutamate receptor sites
  • NMDA: antagonists are known to cause analgesia, anesthesia, dissociation, hallucinations, and euphoria (dissociatives)
  • Kainate: CNS excitant, induces seizures, excitotoxic
  • AMPA: ???
• Ligand types
  • Agonist: binds to and activates receptor directly (usually leads to tolerance and addiction) (i.e. alcohol)
  • Antagonist: binds to but does not activate the receptor, essentially blocking its activation
  • Inverse agonist: binds to receptors and reduces their activity
  • Positive allosteric modulator (PAM): increase the affinity for a receptor without binding/activating it directly (i.e. benzos)
    • Essentially lowers the activation threshold for a receptor, requiring less of an agonist to activate the same response

Compounds

• Chinese Skullcap Benzo agonist/PAM
  • Baicalein is well absorbed and crosses the BBB
  • Wogonin is a GABAA benzo-binding agonist
  • Baicalein is a GABAA agonist for α2 and α3 subunits
  • K36 is a GABAA PAM, 54% diazepam
  • Scutellarein is a GABAA benzo-binding agonist
  • Oroxylin A is a dopamine transport inhibitor, like Ritalin
  • Oroxylin A and wogonin are anti-inflammatory
  • Reportedly non-sedative
• L-Theanine Glutamate inhibitor
  • Increases glycine by 17.2% for one week
  • Increases α-1-waves within 30-45m orally
  • At certain

Tried taking it at night, was up till like 3am, took it in the morning still couldn't get to sleep whats going on I thought people use it for sleep. I have Chronic Fatigue, ADD and anxiety symptoms so does that play a role at all as it works on NMDA receptors?

Introduction to D-Serine

How can one drug help everyone? We constantly hear about people's different experiences, but at the end of the day we all learn in the same way. And this is why I've been fascinated by D-Serine for the past few months. In this post I hope to explore D-Serine in its entirety, from the human trials down to the mechanistic workings in the brain, as I believe this is something that could truly help a wide variety of people.

In summary, this is what I know about its use in humans:

• Nootropic effect of D-Serine in young, healthy people: Reduces sadness and anxiety. Improves attention, learning performance and information retention.^([1])
• Nootropic effect of D-Serine in old, healthy people: Improves spatial memory, learning and problem solving. Didn't change mood.^([17])
• Outlier to the two studies above: Surprisingly, D-Serine failed to improve cognition in different tests that were emotionally charged, suggesting its nootropic effect may not be universally applicable.^([18])
• D-Serine benefits in PTSD: Improves anxiety, depression and general PTSD symptoms.^([15])
• D-Serine benefits in Parkinson's: Significantly improves symptoms in parkinson's patients.^([16])
• D-Serine benefits in Schizophrenia: Significantly improves Positive, Negative and cognitive symptoms of Schizophrenia. Meta analysis.^([8])

Other on-going trials for D-Serine I am aware of: Depression, Schizophrenia (auditory learning) and Psychosis.

D-Serine as a supplement

When taken orally, D-Serine can be used to enhance learning. It seems widely applicable, capable of not only enhancing cognition in healthy people, but those with serious disorders as well. D-Serine has the stereotypical benefits of both NMDA antagonists and glutamatergic drugs.

D-Serine also stimulates adult neurogenesis[^([31])](https://ww

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

[Updated version of this post]

Introduction

• YouTube Clip (1m:37s): "50% of the population does not get adequate magnesium."

Why you could have a magnesium deficiency?

• Magnesium deficiency is strongly correlated with anxiety.
• Other possible symptoms are heart palpitations, leg cramps, vertigo, panic attacks, hypertension, IBS, acid reflux.
• Some of these symptoms could also be caused by vasoconstriction which can lead to an increase in blood pressure - so measurable with a blood pressure machine. Magnesium acts as a vasodilator.

https://preview.redd.it/710nj580req71.jpg?width=2262&format=pjpg&auto=webp&s=5f24839f9622c3acb7ac3c832650919f54b3d715

• As less than 1% of your total body magnesium is stored in the blood the standard (& cheapest) serum blood test is not a good indicator for a deficiency. The magnesium RBC blood test is slightly better. From: Magnesium: Are We Consuming Enough? [Dec 2018]

>In humans, red blood cell (RBC) magnesium levels often provide a better reflection of body magnesium status than blood magnesium levels. When the magnesium concentration in the blood is low, magnesium is pulled out from the cells to maintain blood magnesium levels within normal range. Therefore, in case of magnesium deficiency, a blood test of magnesium might show normal levels, while an RBC magnesium test would provide a more accurate reflection of magnesium status of the body. For exact estimation of RBC magnesium level, individuals are advised not to consume vitamins, or mineral supplements for at least one week before collection of RBC samples. A normal RBC magnesium level ranges between 4.2 and 6.8 mg/dL. However, some experts recommend aiming for a minimum level of 6.0 mg/dL on the RBC test.

• Some have suggested the magnesium RBC test combined with the magnesium urine test would give a better diagnosis.
• Getting the RDA of magnesium from diet can be difficult unless you eat a lot of things like pumpkin seeds, almonds, ground flaxseed, spinach. Spinach also contains a healthy source of nitrates as well as magnesium w

The doctor says it terminal.

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

Do your worst!

How the hell am I suppose to know when it’s raining in Sweden?

Mathematical puns makes me number

We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.

Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

They were cooked in Greece.

I'm surprised it hasn't decade.

He lost May

Now that I listen to albums, I hardly ever leave the house.

The nurse asked the rabbit, “what is your blood type?”

“I am probably a type O” said the rabbit.

Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"

Then the other muffin says "AHH, TALKING MUFFIN!!!"

Don't you know a good pun is its own reword?

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies 😂

It really does, I swear!

And now I’m cannelloni

Because she wanted to see the task manager.

But that’s comparing apples to oranges

And boy are my arms legs.

Put it on my bill

Heard they've been doing some shady business.

but then I remembered it was ground this morning.

Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale

Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments

BamBOO!

They’re on standbi

A play on words.

I initially thought that L-Theanine antagonized all three glutamate receptors, as says the examine.com research page and cited source. However, Wikipedia has a source that says it is an antagonist for AMPA and kainate, but an agonist for NMDA.

https://examine.com/supplements/theanine/research/#neurology_glutaminergic-mechanisms

>Theanine is an antagonist of the NMDA receptors (albeit with fairly weak efficacy) and can inhibit synaptic release of glutamate via blocking the transporter competitively. Theanine may also reduce glutamate levels, but this is also a fairly weak mechanism requiring a high concentration of theanine

But then there is contradictory evidence here that says L-Theanine's NMDA receptor effects are potentially counteracted by a competitive antagonist:

>Oddly, some mechanisms of theanine are blocked by NMDA antagonists. This suggests that higher concentrations of theanine may have their properties dependent on NMDA signalling

I found the study that Examine was citing: https://sci-hub.se/10.1271/bbb.66.2683

>The binding of theanine with the NMDA receptors was 30,000-fold less than that of L-glutamic acid in this study .... reported that theanine administration in the brain striatum increases dopamine release, but that theanine-induced dopamine release is inhibited with treatment by D-APV. Maruyama and Takeda17) suggested that theanine is a competitive antagonist on glutamate receptors, but that its binding activity is not as strong .... These results suggested that there were antagonistic aspects of theanine on the NMDA receptor providing neuroprotective action, although the binding activity of theanine on NMDA receptors was one of order of magnitude lower than on AMPA and kainate receptors.

So to me it sounds like they found that L-Theanine binds strongly to AMPA and kainate receptors, but less so to NDMA receptors, in which it does not ACTIVATE the receptors but blocks the uptake of glutamate, preventing transmissions?

The study that Wikipedia sources that claims L-Theanine is an antagonist for AMPA and kainate but an agonist for NMDA is here: https://sci-hub.se/10.1007/s00213-011-2440-z

>To determine whether L-theanine has agonistic action on the NMDA receptor, we performed Fluo-3 intracellular Ca2+ imaging in culture