Glycine and l-Arginine Treatment Causes Hyperhomocysteinemia in Cerebral Creatine Transporter Deficiency Patients ncbi.nlm.nih.gov/pmc/arti…
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πŸ‘€︎ u/jumpychimp
πŸ“…︎ Mar 06 2021
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Analgesic effect of GT-0198, a structurally novel glycine transporter 2 inhibitor, in a mouse model of neuropathic pain [J Pharmacol Sci., Mar 2015 β€” free full-text] doi.org/10.1016/j.jphs.20…
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πŸ‘€︎ u/isosafrole
πŸ“…︎ Apr 06 2016
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Is it okay to take a Magnesium Transporter/Complex with Citrate, Taurine, Malate, Glycinate and Asparate together?

Its been working but Ive read so much conflicting infomraiton here.

Its a now foods brand. https://www.amazon.com/Foods-Magnesium-Transporters-Capsules-Count/dp/B07JQFPL61

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πŸ‘€︎ u/sashaatx
πŸ“…︎ Apr 14 2021
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Been using ZMA and Magnesium Glycinat for sleep but I still wake up after 4 hours of sleep. Doing my best to have optimal sleep hygiene. Could it be that the Magnesium in the ZMA counteracts the Glycinat? Is it safe to take both of the Supps? reddit.com/gallery/s3tkru
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πŸ‘€︎ u/magenbutter3420
πŸ“…︎ Jan 14 2022
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My compiled research on GABAergic supplements + possible stacks

All of my information has been compiled from examine.com, and in cases where I did not find the research sufficient (namely Rosmarinic Acid), I found a scientific study to cite. My goal was to compile a bunch of GABAergics into digestible bullet-points for future reference in creating stacks.

I also included a few non-GABAergics that I wanted to know more about.

IF ANY INFORMATION IS WRONG, please let me know, ideally with a source attached so I can amend the document :)

ALSO, the synergies / stacks at the bottom are just speculation, I have not tried these yet nor can I confirm if they are effective.

Helpful information

  • GABA receptor sites
    • A
      • alpha-1: addictive, tolerance building, impairing, sedating, amnesia (i.e. benzos)
      • alpha-2 and alpha-3: reduced abuse potential, anxiolytic and muscle relaxation
      • alpha-5: memory impairment
    • B: effects are similar to GABAA but less sedating, typically more clear headed (i.e. baclofen, GHB, phenibut)
  • Enzymes
    • GABA-transaminase (GABA-T): GABA β†’ glutamate
    • Glutamate decarboxylase (GAD): glutamate β†’ GABA
  • Glutamate receptor sites
    • NMDA: antagonists are known to cause analgesia, anesthesia, dissociation, hallucinations, and euphoria (dissociatives)
    • Kainate: CNS excitant, induces seizures, excitotoxic
    • AMPA: ???
  • Ligand types
    • Agonist: binds to and activates receptor directly (usually leads to tolerance and addiction) (i.e. alcohol)
    • Antagonist: binds to but does not activate the receptor, essentially blocking its activation
    • Inverse agonist: binds to receptors and reduces their activity
    • Positive allosteric modulator (PAM): increase the affinity for a receptor without binding/activating it directly (i.e. benzos)
      • Essentially lowers the activation threshold for a receptor, requiring less of an agonist to activate the same response

Compounds

  • Chinese Skullcap Benzo agonist/PAM
    • Baicalein is well absorbed and crosses the BBB
    • Wogonin is a GABAA benzo-binding agonist
    • Baicalein is a GABAA agonist for Ξ±2 and Ξ±3 subunits
    • K36 is a GABAA PAM, 54% diazepam
    • Scutellarein is a GABAA benzo-binding agonist
    • Oroxylin A is a dopamine transport inhibitor, like Ritalin
    • Oroxylin A and wogonin are anti-inflammatory
    • Reportedly non-sedative
  • L-Theanine Glutamate inhibitor
    • Increases glycine by 17.2% for one week
    • Increases Ξ±-1-waves within 30-45m orally
    • At certain
... keep reading on reddit ➑

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πŸ‘€︎ u/AbsoluteChungus1
πŸ“…︎ Dec 02 2021
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Why does Glycine give me horrible insomnia?

Tried taking it at night, was up till like 3am, took it in the morning still couldn't get to sleep whats going on I thought people use it for sleep. I have Chronic Fatigue, ADD and anxiety symptoms so does that play a role at all as it works on NMDA receptors?

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πŸ‘€︎ u/999liveforever
πŸ“…︎ Aug 22 2021
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D-Serine: The holy grail of cognitive enhancers?

Introduction to D-Serine

How can one drug help everyone? We constantly hear about people's different experiences, but at the end of the day we all learn in the same way. And this is why I've been fascinated by D-Serine for the past few months. In this post I hope to explore D-Serine in its entirety, from the human trials down to the mechanistic workings in the brain, as I believe this is something that could truly help a wide variety of people.

In summary, this is what I know about its use in humans:

  • Nootropic effect of D-Serine in young, healthy people: Reduces sadness and anxiety. Improves attention, learning performance and information retention.^([1])
  • Nootropic effect of D-Serine in old, healthy people: Improves spatial memory, learning and problem solving. Didn't change mood.^([17])
  • Outlier to the two studies above: Surprisingly, D-Serine failed to improve cognition in different tests that were emotionally charged, suggesting its nootropic effect may not be universally applicable.^([18])
  • D-Serine benefits in PTSD: Improves anxiety, depression and general PTSD symptoms.^([15])
  • D-Serine benefits in Parkinson's: Significantly improves symptoms in parkinson's patients.^([16])
  • D-Serine benefits in Schizophrenia: Significantly improves Positive, Negative and cognitive symptoms of Schizophrenia. Meta analysis.^([8])

Other on-going trials for D-Serine I am aware of: Depression, Schizophrenia (auditory learning) and Psychosis.

D-Serine as a supplement

When taken orally, D-Serine can be used to enhance learning. It seems widely applicable, capable of not only enhancing cognition in healthy people, but those with serious disorders as well. D-Serine has the stereotypical benefits of both NMDA antagonists and glutamatergic drugs.

D-Serine also stimulates adult neurogenesis[^([31])](https://ww

... keep reading on reddit ➑

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πŸ‘€︎ u/sirsadalot
πŸ“…︎ Dec 18 2021
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SERIOUS: This subreddit needs to understand what a "dad joke" really means.

I don't want to step on anybody's toes here, but the amount of non-dad jokes here in this subreddit really annoys me. First of all, dad jokes CAN be NSFW, it clearly says so in the sub rules. Secondly, it doesn't automatically make it a dad joke if it's from a conversation between you and your child. Most importantly, the jokes that your CHILDREN tell YOU are not dad jokes. The point of a dad joke is that it's so cheesy only a dad who's trying to be funny would make such a joke. That's it. They are stupid plays on words, lame puns and so on. There has to be a clever pun or wordplay for it to be considered a dad joke.

Again, to all the fellow dads, I apologise if I'm sounding too harsh. But I just needed to get it off my chest.

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πŸ‘€︎ u/anywhereiroa
πŸ“…︎ Jan 15 2022
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How Vitamin D And Magnesium Work Together: "50% of the population does not get adequate magnesium."

[Updated version of this post]

Introduction

Why you could have a magnesium deficiency?

  • Magnesium deficiency is strongly correlated with anxiety.
  • Other possible symptoms are heart palpitations, leg cramps, vertigo, panic attacks, hypertension, IBS, acid reflux.
  • Some of these symptoms could also be caused by vasoconstriction which can lead to an increase in blood pressure - so measurable with a blood pressure machine. Magnesium acts as a vasodilator.

https://preview.redd.it/710nj580req71.jpg?width=2262&format=pjpg&auto=webp&s=5f24839f9622c3acb7ac3c832650919f54b3d715

  • As less than 1% of your total body magnesium is stored in the blood the standard (& cheapest) serum blood test is not a good indicator for a deficiency. The magnesium RBC blood test is slightly better. From: Magnesium: Are We Consuming Enough? [Dec 2018]

>In humans, red blood cell (RBC) magnesium levels often provide a better reflection of body magnesium status than blood magnesium levels. When the magnesium concentration in the blood is low, magnesium is pulled out from the cells to maintain blood magnesium levels within normal range. Therefore, in case of magnesium deficiency, a blood test of magnesium might show normal levels, while an RBC magnesium test would provide a more accurate reflection of magnesium status of the body. For exact estimation of RBC magnesium level, individuals are advised not to consume vitamins, or mineral supplements for at least one week before collection of RBC samples. A normal RBC magnesium level ranges between 4.2 and 6.8 mg/dL. However, some experts recommend aiming for a minimum level of 6.0 mg/dL on the RBC test.

  • Some have suggested the magnesium RBC test combined with the magnesium urine test would give a better diagnosis.
  • Getting the RDA of magnesium from diet can be difficult unless you eat a lot of things like pumpkin seeds, almonds, ground flaxseed, spinach. Spinach also contains a healthy source of nitrates as well as magnesium w
... keep reading on reddit ➑

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πŸ‘€︎ u/NeuronsToNirvana
πŸ“…︎ Sep 27 2021
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I’ve got this disease where I can’t stop making airport puns.

The doctor says it terminal.

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πŸ‘€︎ u/xIR0NPULSE
πŸ“…︎ Jan 28 2022
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Just because it's a joke, doesn't mean it's a dad joke

Alot of great jokes get posted here! However just because you have a joke, doesn't mean it's a dad joke.

THIS IS NOT ABOUT NSFW, THIS IS ABOUT LONG JOKES, BLONDE JOKES, SEXUAL JOKES, KNOCK KNOCK JOKES, POLITICAL JOKES, ETC BEING POSTED IN A DAD JOKE SUB

Try telling these sexual jokes that get posted here, to your kid and see how your spouse likes it.. if that goes well, Try telling one of your friends kid about your sex life being like Coca cola, first it was normal, than light and now zero , and see if the parents are OK with you telling their kid the "dad joke"

I'm not even referencing the NSFW, I'm saying Dad jokes are corny, and sometimes painful, not sexual

So check out r/jokes for all types of jokes

r/unclejokes for dirty jokes

r/3amjokes for real weird and alot of OC

r/cleandadjokes If your really sick of seeing not dad jokes in r/dadjokes

Punchline !

Edit: this is not a post about NSFW , This is about jokes, knock knock jokes, blonde jokes, political jokes etc being posted in a dad joke sub

Edit 2: don't touch the thermostat

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πŸ‘€︎ u/CzarcasmRules
πŸ“…︎ Jan 23 2022
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Blind Girl Here. Give Me Your Best Blind Jokes!

Do your worst!

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πŸ‘€︎ u/Leckzsluthor
πŸ“…︎ Jan 02 2022
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I heard that by law you have to turn on your headlights when it’s raining in Sweden.

How the hell am I suppose to know when it’s raining in Sweden?

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πŸ‘€︎ u/justshtmypnts
πŸ“…︎ Jan 25 2022
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Puns make me numb

Mathematical puns makes me number

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πŸ‘€︎ u/tadashi4
πŸ“…︎ Jan 26 2022
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So my mom is getting her foot cut off today.. (really)

We told her she can lean on us for support. Although, we are going to have to change her driver's license, her height is going down by a foot. I don't want to go too far out on a limb here but it better not be a hack job.

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πŸ‘€︎ u/Slimybirch
πŸ“…︎ Jan 27 2022
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Petition to ban rants from this sub

Ants don’t even have the concept fathers, let alone a good dad joke. Keep r/ants out of my r/dadjokes.

But no, seriously. I understand rule 7 is great to have intelligent discussion, but sometimes it feels like 1 in 10 posts here is someone getting upset about the jokes on this sub. Let the mods deal with it, they regulate the sub.

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πŸ‘€︎ u/drak0ni
πŸ“…︎ Jan 24 2022
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French fries weren’t cooked in France.

They were cooked in Greece.

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πŸ“…︎ Jan 20 2022
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This subreddit is 10 years old now.

I'm surprised it hasn't decade.

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πŸ‘€︎ u/frexyincdude
πŸ“…︎ Jan 14 2022
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Why does Spider-Man's calendar only have 11 months?

He lost May

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πŸ‘€︎ u/Toku-Nation
πŸ“…︎ Jan 26 2022
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When I was a single man, I had loads of free time.

Now that I listen to albums, I hardly ever leave the house.

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πŸ‘€︎ u/porichoygupto
πŸ“…︎ Jan 25 2022
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You've been hit by
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πŸ‘€︎ u/mordrathe
πŸ“…︎ Jan 20 2022
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A priest, a pastor, and a rabbit walk into a blood donation clinic.

The nurse asked the rabbit, β€œwhat is your blood type?”

β€œI am probably a type O” said the rabbit.

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πŸ‘€︎ u/snc8698
πŸ“…︎ Jan 29 2022
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My 4 year oldest favourit joke, which he very proudly memorized and told all his teachers.

Two muffins are in an oven, one muffin looks at the other and says "is it just me, or is it hot in here?"

Then the other muffin says "AHH, TALKING MUFFIN!!!"

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πŸ‘€︎ u/smoffatt34920
πŸ“…︎ Jan 22 2022
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I'm sick of you guys posting dumb wordplay in here for awards and upvotes.

Don't you know a good pun is its own reword?

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πŸ‘€︎ u/diggitygiggitycee
πŸ“…︎ Jan 21 2022
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Dropped my best ever dad joke & no one was around to hear it

For context I'm a Refuse Driver (Garbage man) & today I was on food waste. After I'd tipped I was checking the wagon for any defects when I spotted a lone pea balanced on the lifts.

I said "hey look, an escaPEA"

No one near me but it didn't half make me laugh for a good hour or so!

Edit: I can't believe how much this has blown up. Thank you everyone I've had a blast reading through the replies πŸ˜‚

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πŸ‘€︎ u/Vegetable-Acadia
πŸ“…︎ Jan 11 2022
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What starts with a W and ends with a T

It really does, I swear!

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πŸ‘€︎ u/PsychedeIic_Sheep
πŸ“…︎ Jan 13 2022
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My wife left me because I couldn’t stop doing impressions of pasta

And now I’m cannelloni

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πŸ‘€︎ u/bluestratmatt
πŸ“…︎ Jan 23 2022
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Why did Karen press Ctrl+Shift+Delete?

Because she wanted to see the task manager.

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πŸ‘€︎ u/Eoussama
πŸ“…︎ Jan 17 2022
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Steve JOBS would have made a better President than Donald Trump

But that’s comparing apples to oranges

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πŸ‘€︎ u/Ok-Ingenuity4838
πŸ“…︎ Jan 22 2022
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I just flew in from Chernobyl

And boy are my arms legs.

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πŸ‘€︎ u/JhopkinsWA
πŸ“…︎ Jan 23 2022
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My 7 year old daughter just told me this one. I'm so proud. What did the duck say when he bought chapstick?

Put it on my bill

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πŸ‘€︎ u/BigRedHusker_X
πŸ“…︎ Jan 26 2022
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So 2 trees got arrested in the town I live...

Heard they've been doing some shady business.

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πŸ‘€︎ u/K1ll47h3K1n9
πŸ“…︎ Jan 18 2022
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I was almost upset that my coffee tasted like dirt today

but then I remembered it was ground this morning.

Edit: Thank you guys for the awards, they're much nicer than the cardboard sleeve I've been using and reassures me that my jokes aren't stale

Edit 2: I have already been made aware that Men In Black 3 has told a version of this joke before. If the joke is not new to you, please enjoy any of the single origin puns in the comments

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πŸ‘€︎ u/scarf_spheal
πŸ“…︎ Jan 19 2022
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No gains
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πŸ‘€︎ u/ridi86
πŸ“…︎ Jan 22 2022
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How eggs-traordinary
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πŸ‘€︎ u/Rix27_
πŸ“…︎ Jan 21 2022
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Duckduckgo
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πŸ‘€︎ u/findmebatman
πŸ“…︎ Jan 28 2022
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Geometry sucks
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πŸ‘€︎ u/Kash30
πŸ“…︎ Jan 25 2022
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What is the scariest tree?

BamBOO!

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πŸ‘€︎ u/K1ll47h3K1n9
πŸ“…︎ Jan 18 2022
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What is a a bisexual person doing when they’re not dating anybody?

They’re on standbi

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πŸ‘€︎ u/Toby-the-Cactus
πŸ“…︎ Jan 12 2022
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My ten-year-old daughter came up with this at dinner tonight: What do you get if put a copy of Macbeth on top of a dictionary?

A play on words.

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πŸ‘€︎ u/ah1887
πŸ“…︎ Jan 20 2022
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A queen size statement.
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πŸ‘€︎ u/Flight-less
πŸ“…︎ Jan 22 2022
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Is L-Theanine an NMDA antagonist, agonist, or co-agonist?

I initially thought that L-Theanine antagonized all three glutamate receptors, as says the examine.com research page and cited source. However, Wikipedia has a source that says it is an antagonist for AMPA and kainate, but an agonist for NMDA.

https://examine.com/supplements/theanine/research/#neurology_glutaminergic-mechanisms

>Theanine is an antagonist of the NMDA receptors (albeit with fairly weak efficacy) and can inhibit synaptic release of glutamate via blocking the transporter competitively. Theanine may also reduce glutamate levels, but this is also a fairly weak mechanism requiring a high concentration of theanine

But then there is contradictory evidence here that says L-Theanine's NMDA receptor effects are potentially counteracted by a competitive antagonist:

>Oddly, some mechanisms of theanine are blocked by NMDA antagonists. This suggests that higher concentrations of theanine may have their properties dependent on NMDA signalling

I found the study that Examine was citing: https://sci-hub.se/10.1271/bbb.66.2683

>The binding of theanine with the NMDA receptors was 30,000-fold less than that of L-glutamic acid in this study .... reported that theanine administration in the brain striatum increases dopamine release, but that theanine-induced dopamine release is inhibited with treatment by D-APV. Maruyama and Takeda17) suggested that theanine is a competitive antagonist on glutamate receptors, but that its binding activity is not as strong .... These results suggested that there were antagonistic aspects of theanine on the NMDA receptor providing neuroprotective action, although the binding activity of theanine on NMDA receptors was one of order of magnitude lower than on AMPA and kainate receptors.

So to me it sounds like they found that L-Theanine binds strongly to AMPA and kainate receptors, but less so to NDMA receptors, in which it does not ACTIVATE the receptors but blocks the uptake of glutamate, preventing transmissions?

The study that Wikipedia sources that claims L-Theanine is an antagonist for AMPA and kainate but an agonist for NMDA is here: https://sci-hub.se/10.1007/s00213-011-2440-z

>To determine whether L-theanine has agonistic action on the NMDA receptor, we performed Fluo-3 intracellular Ca2+ imaging in culture

... keep reading on reddit ➑

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πŸ‘€︎ u/AbsoluteChungus1
πŸ“…︎ Dec 02 2021
🚨︎ report

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