The interest in indole dearomatization, which serves as a useful tool in the total synthesis of related alkaloid natural products, has recently been renewed with the intention of developing new methods efficient in both yield and stereoselective control. Here, we report an enzymatic approach for the oxidative dearomatization of indoles in the asymmetric synthesis of a variety of furoindolines with a vicinal quaternary carbon stereogenic center. This approach depends on the activity of a flavin‐dependent monooxygenase, TsrE, which is involved in the biosynthesis of bicyclic thiopeptide antibiotic thiostrepton. TsrE catalyzes 2,3‐epoxidation and subsequent epoxide opening in a highly enantioselective manner during the conversion of 2‐methyl‐indole‐3‐acetic acid or 2‐methyl‐tryptophol to furoindoline , with up to > 99% conversion and > 99% ee under mild reaction conditions. Complementing current chemical methods for oxidative indole dearomatization, the TsrE activity‐based approach enriches the toolbox in the asymmetric synthesis of products possessing a furoindoline skeleton.
https://ift.tt/39lvj32
Found in the time capsule. There’s one book that’s a nautical almanac and another that’s titled something “lovers.” All contents are wet so they need time to discover more details.
Edit: the envelope contains a document and a possible graphite photo. From what I could see (I’m not a professional so this is just what I saw) the photo had an address on the bottom 525 E Broad St
One of the first ever Bitcoin miners has left his wallet untouched for over 11 years. He now shows activity again.
His wallet contains 50 Bitcoin, worth about $3,000,000.
At the time of when he was mining, a Bitcoin was worth about $0,06 each, all his Bitcoin were worth $3:
This is a 76,249,900% increase in value over the past 11 years.
def main():
_list_ = []
for i in range(2, 10001):
_list_.append(i)
k=0
while k<10000-2:# n starts from 2
n = _list_[k]
multiple = 2*n
while multiple <= 10000:
multiple += n
_list_.remove(multiple)
k = k + 1
main()
ValueError: list.remove(x): x not in list
i dont know what im doing wrong here can anyone help
This is a simple app which respects your privacy. It is completely free and open source.
The app uses a query client which connects every set amount of time. You can adjust this time between 15 and 120 minutes. The client connects, gets the clients online and then disconnects.
The app saves the ip and login credentials offline on your device and encrypted. There are no trackers or analytics tools like Google Firebase and Analytics.
Please read the README carefully if you plan to use this app.
Have fun using it!
